BlogPart 1Cold Case - Part 1: The Cold Case Files
Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
Cold Case: When Brain Tissue Holds the Evidence
Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
1
BlogPart 12
BlogPart 2Cold Case - Part 2: Contaminated Evidence
Manual extraction of nuclei from FFPE brain tissue destroys 50 to 60 percent of starting material. Fragile neurons die first, leaving biased results. Here is what goes wrong.
3
BlogPart 3Cold Case - Part 3: One Shot at the Scene
NIH biobanks give you one allocation of irreplaceable brain tissue. Manual processing destroys 50-60% before analysis begins. The extraction method is the real variable.
4
BlogPart 4Cold Case - Part 4: The Forensic Lab
Manual FFPE processing destroys fragile neuronal nuclei and produces variable results. The Singulator 200+ automates the workflow with a two-cartridge system that delivers consistent, operator-independent results from irreplaceable brain tissue.
5
BlogPart 5Cold Case - Part 5: Case Closed
Brain atlases are being built. Archival tissue is finally talking. How standardized nuclei extraction and platform-agnostic analysis are solving neuroscience's oldest cold cases.