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- Cold Case: When Brain Tissue Holds the Evidence Blog Series 5 parts
# Cold Case: When Brain Tissue Holds the Evidence

Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
1 [Blog Part 1](/resources/cold-case-files-brain-tissue-evidence/) Singulator 200+
### Cold Case - Part 1: The Cold Case Files

Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
[Read Blog](/resources/cold-case-files-brain-tissue-evidence/) 2 [Blog Part 2](/resources/cold-case-contaminated-evidence-brain-tissue/) Singulator 200+
### Cold Case - Part 2: Contaminated Evidence

Manual extraction of nuclei from FFPE brain tissue destroys 50 to 60 percent of starting material. Fragile neurons die first, leaving biased results. Here is what goes wrong.
[Read Blog](/resources/cold-case-contaminated-evidence-brain-tissue/) 3 [Blog Part 3](/resources/cold-case-one-shot-at-the-scene/) Singulator 200+
### Cold Case - Part 3: One Shot at the Scene

NIH biobanks give you one allocation of irreplaceable brain tissue. Manual processing destroys 50-60% before analysis begins. The extraction method is the real variable.
[Read Blog](/resources/cold-case-one-shot-at-the-scene/) 4 [Blog Part 4](/resources/cold-case-forensic-lab-singulator-200-plus/) Singulator 200+
### Cold Case - Part 4: The Forensic Lab

Manual FFPE processing destroys fragile neuronal nuclei and produces variable results. The Singulator 200+ automates the workflow with a two-cartridge system that delivers consistent, operator-independent results from irreplaceable brain tissue.
[Read Blog](/resources/cold-case-forensic-lab-singulator-200-plus/) 5 [Blog Part 5](/resources/cold-case-closed-brain-atlas/) Singulator 200+
### Cold Case - Part 5: Case Closed

Brain atlases are being built. Archival tissue is finally talking. How standardized nuclei extraction and platform-agnostic analysis are solving neuroscience's oldest cold cases.
[Read Blog](/resources/cold-case-closed-brain-atlas/)