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# Singulator Resources
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[Field Guide](/resources/brain-tissue-complexity-myelin-lipids-neuronal-nuclei/) Singulator 200+
### Overcoming Brain Tissue Complexity: Myelin, Lipids, and Fragile Neuronal Nuclei

Brain FFPE tissue creates unique nuclei isolation challenges. Myelin debris, lipid contamination, and fragile neuronal nuclei require controlled automated processing to preserve cell-type diversity for single-nucleus sequencing.
[Read Field Guide](/resources/brain-tissue-complexity-myelin-lipids-neuronal-nuclei/) [Field Guide](/resources/brain-tumor-ffpe-surgical-resection-single-cell/) Singulator 200+
### Brain Tumor FFPE Processing: From Surgical Resection to Single-Nucleus Insights

Process brain tumor FFPE from surgical resections on the Singulator 200+. Preserve cancer cells and immune populations for snRNA-seq and spatial analysis.
[Read Field Guide](/resources/brain-tumor-ffpe-surgical-resection-single-cell/) [Ebook](/resources/cold-case-files-neuroscience-ffpe/) Singulator 200+
### Cold Case Files:The Brain's Embedded Evidence

How the Singulator 200+ preserves fragile neuronal nuclei from irreplaceable postmortem brain tissue. Automated FFPE processing for Alzheimer's, brain tumors, and brain atlases.
[Read Ebook](/resources/cold-case-files-neuroscience-ffpe/) [Field Guide](/resources/ffpe-neurodegenerative-disease-research-singulator/) Singulator 200+
### FFPE Nuclei Extraction for Neurodegenerative Disease Research

Extract nuclei from FFPE brain tissue for Alzheimer's, Parkinson's, and Lewy body research. Longitudinal cohorts, cell-type preservation, and disease staging on the Singulator 200+.
[Read Field Guide](/resources/ffpe-neurodegenerative-disease-research-singulator/) [Field Guide](/resources/integrating-snrna-seq-spatial-transcriptomics-brain-ffpe/) Singulator 200+
### Integrating snRNA-seq with spatial transcriptomics for brain mapping

Pair spatial transcriptomics with snRNA-seq from the same FFPE brain block. Block allocation, platform selection, and nuclei quality for multi-omic brain studies.
[Read Field Guide](/resources/integrating-snrna-seq-spatial-transcriptomics-brain-ffpe/) [Field Guide](/resources/maximizing-limited-brain-tissue-sections-ffpe/) Singulator 200+
### Maximizing Results from Limited Brain Tissue Sections

Get high-quality nuclei from limited postmortem brain FFPE sections. Process NIH biobank allocations, hospital archives, and surgical specimens on the Singulator 200+.
[Read Field Guide](/resources/maximizing-limited-brain-tissue-sections-ffpe/) [Field Guide](/resources/navigating-postmortem-brain-tissue-ffpe-genomics/) Singulator 200+
### Navigating postmortem brain tissue for FFPE genomics

Practical guide to postmortem brain FFPE challenges: necropsy timing, fixation variability, biobank sourcing, myelin debris, and how the Singulator 200+ standardizes nuclei extraction.
[Read Field Guide](/resources/navigating-postmortem-brain-tissue-ffpe-genomics/) [Field Guide](/resources/reproducible-multi-site-brain-tissue-atlases-singulator/) Singulator 200+
### Building Reproducible Multi-Site Brain Tissue Atlases

Standardize brain FFPE nuclei extraction across consortium sites with the Singulator 200+. Eliminate operator variability, prevent batch effects, and scale for atlas projects.
[Read Field Guide](/resources/reproducible-multi-site-brain-tissue-atlases-singulator/) [Webinar](/resources/unlocking-single-cell-insights-from-ffpe-samples/) Singulator 200+
### Unlocking Single-Cell Insights from FFPE Samples

Ronan Chaugnet from Memorial Sloan Kettering shares several years of head-to-head benchmarking data comparing nuclei extraction platforms for FFPE tissue. The Singulator 200+ and Miltenyi GentleMACS both outperformed manual approaches across glioblastoma, liver, lung, pancreas, and tumor samples, with the Singulator 200+ standing out for its fully automated, enzyme-free workflow. Ronan also walks through three methods his lab has built on top of automated FFPE extraction: 10X Genomics FLEX for high-quality gene expression, PERFF-Seq for sorting rare cell populations by RNA markers, and GIFT-Seq for detecting 600+ mutations at single-cell resolution from archival tissue.
[Read More](/resources/unlocking-single-cell-insights-from-ffpe-samples/) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/Automating-Nuclei-Isolation-from-FFPE-Tissues-for-Single-Nuclei-Sequencing-Applications.pdf) Singulator 200+
### Automating Nuclei Isolation from FFPE Tissues for Single-Nuclei Sequencing Applications

This protocol describes how to isolate, count, and prepare single nuclei from FFPE (formalin-fixed, paraffin-embedded) tissues for single-nuclei sequencing assays using the Singulator 200+ platform. Deparaffinization and rehydration of the tissue using solvent and various concentrations of ethanol are conducted on the Singulator 200+ platform along with automated nuclei isolation.
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/Automating-Nuclei-Isolation-from-FFPE-Tissues-for-Single-Nuclei-Sequencing-Applications.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0004-PCS-Demonstrated-Protocol-nuclei-isolation-from-FFPE-v241118.pdf) Singulator 100 Singulator 200
### Nuclei extraction from FFPE

This protocol describes how to isolate, count, and prepare single nuclei from FFPE (formalin-fixed,paraffin-embedded) tissues for single-nuclei sequencing assays using the Singulator Platform.
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0004-PCS-Demonstrated-Protocol-nuclei-isolation-from-FFPE-v241118.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0001-PCS-Cell-Isolation-from-Intestine-Tissue-for-Single-Cell-Sequencing-Applications-Demonstrated-Protocol.pdf) Singulator 100 Singulator 200
### Cell Isolation from Intestine Tissue for Single Cell Sequencing Applications Demonstrated Protocol

This protocol outlines the process for isolating, cleaning, counting, and preparing single cells fromfresh intestine tissue for single-cell sequencing assays listed below. Some
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0001-PCS-Cell-Isolation-from-Intestine-Tissue-for-Single-Cell-Sequencing-Applications-Demonstrated-Protocol.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0002-PCS-Demonstrated-Protocol-Cell-Isolation-from-Fresh-Tissues-v241218.pdf) Singulator 100 Singulator 200
### Cell Isolation from Fresh Tissues Demonstrated Protocol

This protocol outlines the process for isolating, cleaning, counting, and preparing single cells from fresh tissue for the single-cell sequencing assays listed below
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0002-PCS-Demonstrated-Protocol-Cell-Isolation-from-Fresh-Tissues-v241218.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0003-PCS-genomics-Demonstrated-Protocol-FFPE-and-PFA-fixed-Tissues-Cells-v241206B.pdf) Singulator 100 Singulator 200
### Demonstrated-Protocol-FFPE and PFA fixed Tissues-Cells

This protocol outlines the steps for isolating, counting, and preparing single cells from FFPE (formalin-fixed,paraffin-embedded) or paraformaldehyde (PFA) fixed whole tissues for single-cell sequencing assays using theSingulator™ Platform. The process includes automated deparaffinization, rehydration, and dissociation.
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0003-PCS-genomics-Demonstrated-Protocol-FFPE-and-PFA-fixed-Tissues-Cells-v241206B.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0006-PCS-genomics-demonstrated-protocol-nuclei-isolation-and-cleanup-frozen-mouse-brain-v241018.pdf) Singulator 100 Singulator 200
### demonstrated-protocol-nuclei-isolation-and-cleanup-frozen-mouse-brain-v241018

This protocol describes how to isolate, clean, count, and prepare single nuclei from fresh frozenmouse brain tissue for single-nuclei sequencing applications. Some optimizations of theSingulator™ protocol parameters may be needed based on storage time and tissue condition.
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0006-PCS-genomics-demonstrated-protocol-nuclei-isolation-and-cleanup-frozen-mouse-brain-v241018.pdf) [Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0005-PCS-genomics-Demonstrated-Protocol-nuclei-isolation-and-cleanup-from-frozen-tissue-v241106v2.pdf) Singulator 100 Singulator 200
### Demonstrated-Protocol-nuclei-isolation-and-cleanup-from-frozen-tissue-v241106v2

This protocol describes how to isolate, clean, count, and preparesingle nuclei from frozen tissue for single-nuclei sequencing assays.
[Read Protocol](https://precisioncellsystems.com/wp-content/uploads/2026/03/DP0005-PCS-genomics-Demonstrated-Protocol-nuclei-isolation-and-cleanup-from-frozen-tissue-v241106v2.pdf) [Blog Part 5](/resources/cold-case-closed-brain-atlas/) Singulator 200+
### Cold Case - Part 5: Case Closed

Brain atlases are being built. Archival tissue is finally talking. How standardized nuclei extraction and platform-agnostic analysis are solving neuroscience's oldest cold cases.
[Read Blog](/resources/cold-case-closed-brain-atlas/) [Blog Part 2](/resources/cold-case-contaminated-evidence-brain-tissue/) Singulator 200+
### Cold Case - Part 2: Contaminated Evidence

Manual extraction of nuclei from FFPE brain tissue destroys 50 to 60 percent of starting material. Fragile neurons die first, leaving biased results. Here is what goes wrong.
[Read Blog](/resources/cold-case-contaminated-evidence-brain-tissue/) [Blog Part 1](/resources/cold-case-files-brain-tissue-evidence/) Singulator 200+
### Cold Case - Part 1: The Cold Case Files

Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
[Read Blog](/resources/cold-case-files-brain-tissue-evidence/) [Blog Part 4](/resources/cold-case-forensic-lab-singulator-200-plus/) Singulator 200+
### Cold Case - Part 4: The Forensic Lab

Manual FFPE processing destroys fragile neuronal nuclei and produces variable results. The Singulator 200+ automates the workflow with a two-cartridge system that delivers consistent, operator-independent results from irreplaceable brain tissue.
[Read Blog](/resources/cold-case-forensic-lab-singulator-200-plus/) [Blog Part 3](/resources/cold-case-one-shot-at-the-scene/) Singulator 200+
### Cold Case - Part 3: One Shot at the Scene

NIH biobanks give you one allocation of irreplaceable brain tissue. Manual processing destroys 50-60% before analysis begins. The extraction method is the real variable.
[Read Blog](/resources/cold-case-one-shot-at-the-scene/) [Field Guide](/resources/complete-ffpe-workflow-archive-to-publication-singulator/) Singulator 200+
### Complete FFPE workflow: from archive to publication with the Singulator 200+

End-to-end protocol walkthrough from FFPE block selection through deparaffinization, nuclei isolation, quality control, library preparation, sequencing, and data analysis using the Singulator 200+.
[Read Field Guide](/resources/complete-ffpe-workflow-archive-to-publication-singulator/) [Field Guide](/resources/deparaffinization-rehydration-singulator-200-plus-green-cartridge/) Singulator 200+
### Deparaffinization Rehydration Optimization

How the Singulator 200+ GREEN cartridge automates FFPE deparaffinization and rehydration, eliminating toxic solvents, fume hoods, and manual ethanol series from nuclei extraction workflows.
[Read Field Guide](/resources/deparaffinization-rehydration-singulator-200-plus-green-cartridge/) [Field Guide](/resources/ffpe-downstream-platform-compatibility/) Singulator 200+
### FFPE Downstream Platform Compatibility

Practical guide to connecting Singulator 200+ FFPE nuclei with downstream analysis platforms including 10x Chromium Flex, Xenium, ATAC-seq, Visium, and MERFISH, covering quality requirements, expected yields, and multi-platform study design.
[Read Field Guide](/resources/ffpe-downstream-platform-compatibility/) [Field Guide](/resources/ffpe-input-preparation-optimizing-curl-thickness-tissue-mass-block-age-singulator-200-plus/) Singulator 200+
### FFPE Input Preparation

Practical guide to preparing FFPE tissue inputs for the Singulator 200+ automated nuclei extraction platform, covering curl thickness selection, tissue mass requirements, block age effects, quality assessment, and handling difficult or precious specimens.
[Read Field Guide](/resources/ffpe-input-preparation-optimizing-curl-thickness-tissue-mass-block-age-singulator-200-plus/) [Field Guide](/resources/ffpe-troubleshooting-guide-singulator-200-plus/) Singulator 200+
### FFPE Troubleshooting Guide: Diagnosing and Resolving Common Singulator 200+ Issues

Practical troubleshooting guide for the Singulator 200+ FFPE nuclei extraction workflow, covering the five most common problem categories: low yield, excessive debris, poor RNA quality, batch-to-batch variability, and cartridge/instrument errors.
[Read Field Guide](/resources/ffpe-troubleshooting-guide-singulator-200-plus/) [Field Guide](/resources/minimal-precious-ffpe-samples-singulator-200-plus/) Singulator 200+
### Working with Minimal and Precious FFPE Samples

Practical strategies for maximizing nuclei recovery from limited FFPE tissue on the Singulator 200+, covering block quality assessment, sectioning waste reduction, the pilot curl approach for irreplaceable specimens, handling needle biopsies and crumbly blocks, and preserving nuclei yield post-processing.
[Read Field Guide](/resources/minimal-precious-ffpe-samples-singulator-200-plus/) [Field Guide](/resources/nuclei-isolation-quality-assessment-yield-viability-dv200-ffpe-singulator/) Singulator 200+
### FFPE Nuclei Isolation Quality Assessment

Quality assessment of nuclei isolated from FFPE tissue using the Singulator 200+, covering yield measurement, DAPI staining for morphology, DV200 RNA quality metrics, erythrocyte contamination assessment, and structured go/no-go decision frameworks before downstream sequencing.
[Read Field Guide](/resources/nuclei-isolation-quality-assessment-yield-viability-dv200-ffpe-singulator/) [Ebook](/resources/tissue-dissociation-protocol-guide/) Singulator 100 Singulator 200 Singulator 200+
### Tissue Dissociation Guide

The most comprehensive tissue dissociation reference available. Interactive protocols for single-cell isolation and nuclei extraction across 57+ tissue types with community and Singulator-optimized methods.
[Read Ebook](/resources/tissue-dissociation-protocol-guide/) [Ebook](/resources/unlock-the-archive-ffpe-nuclei-extraction/) Singulator 200+
### Unlock the Archive: Automated FFPE Nuclei Extraction for Single-Cell Genomics

How formalin-fixed paraffin-embedded tissue archives hold enormous potential for single-cell genomics, and how the Singulator 200+ automates the nuclei extraction workflow to unlock that potential
[Read Ebook](/resources/unlock-the-archive-ffpe-nuclei-extraction/) [App Note](https://precisioncellsystems.com/wp-content/uploads/2026/02/Singulator-Application-Note-Cell-Prep-and-Sequencing-Skin-and-Kidney-Cells-with-Parse-Evercode-WT.pdf) Singulator 100 Singulator 200
### Cell Prep and Sequencing Skin and Kidney Cells with Parse Evercode WT

The Singulator platform paired with Parse Biosciences technology enables efficient single-cell
isolation and sequencing from challenging tissue types, with high viability and robust cell
yields suitable for downstream scRNA-seq analysis.
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2026/02/Singulator-Application-Note-Cell-Prep-and-Sequencing-Skin-and-Kidney-Cells-with-Parse-Evercode-WT.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Cell-Sequencing-of-Tumor-Infiltrating-Lymphocytes-in-Lung-Cancer-with-10x.pdf) Singulator 100 Singulator 200
### Single-Cell Sequencing of Tumor-Infiltrating Lymphocytes in Lung Cancer with 10x

These data demonstrate the ability of the Singulator Platform to prepare single-cell suspensions for
both positive selection by a cell surface marker and single-cell RNA sequencing. These methods
enable researchers to identify genes of interest for potential therapeutic targets for anti-tumor
response
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Cell-Sequencing-of-Tumor-Infiltrating-Lymphocytes-in-Lung-Cancer-with-10x.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Nuclei-Sequencing-of-Mouse-Cerebellum.pdf) Singulator 100 Singulator 200
### Single-Nuclei Sequencing of Mouse Cerebellum with 10x

The Singulator™ Platform provides a reproducible and precise method for isolating nuclei from
complex tissues suitable for single-nuclei RNA sequencing. Our results demonstrate consistent nuclei
yield and high-quality sequencing metrics across biological replicates, making it a reliable tool
for neuroscientific research. The ability to produce high-quality nuclei with minimal variability
enhances the accuracy of downstream snRNA analyses, facilitating deeper insights into normal biology
and disease. Finally, the ability to identify rare cell types underscores the efficacy of the
Singulator Platform in comprehensive cellular analysis, providing a detailed representation of the
cellular landscape.
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Nuclei-Sequencing-of-Mouse-Cerebellum.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2026/02/Singulator-Application-Note-Singulator-Use-of-Nuclei-Debris-Removal-Reagent.pdf) Singulator 100 Singulator 200
### Singulator Use of Nuclei Debris Removal Reagent

The presence of intracellular and extracellular debris in single-nucleus RNA sequencing can
present a significant challenge in obtaining reliable and accurate results. However, the use of the Precision
Cell Systems Nuclei Debris Removal Reagent can effectively improve the quality of the samples. Our evaluation
of the Nuclei Debris Removal Reagent shows successful removal of debris from traditionally high-debris samples
of brain and liver nuclei while delivering high quality single nuclei suspensions. The resulting samples are
able to be run through microfluidic single nuclei sequencing platforms without issues of clogging or reduced
data quality
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2026/02/Singulator-Application-Note-Singulator-Use-of-Nuclei-Debris-Removal-Reagent.pdf) [Blog Part 1](/resources/unlocking-ffpe-archives-part-1-the-ffpe-fortune/) Singulator 200+
### Unlocking FFPE Archives - Part 1: The FFPE Fortune - What's Hidden in Your Biobank?

Somewhere in your institution, there's a dusty shelf. Sitting on it: thousands of tissue blocks. Each one holds decades of clinical history. Patient outcomes. Treatment responses. Disease progression. Data that took years to collect. And can you blame researchers for walking past it?
[Read Blog](/resources/unlocking-ffpe-archives-part-1-the-ffpe-fortune/) [Blog Part 2](/resources/unlocking-ffpe-archives-part-2-ffpe-chemistry-problem-preservation-prison/) Singulator 200+
### Unlocking FFPE Archives - Part 2: The Chemistry Problem: Why Preservation Became a Prison

Here's a weird fact: the same chemical that saves your sample also traps everything useful inside it. Think about laminating a document. Great for protection. Terrible if you need to edit what's inside. That's formalin. And for decades, nobody could undo the damage.
[Read Blog](/resources/unlocking-ffpe-archives-part-2-ffpe-chemistry-problem-preservation-prison/) [Blog Part 3](/resources/unlocking-ffpe-archives-part-3-manual-vs-modern-workflow-debate/) Singulator 200+
### Unlocking FFPE Archives - Part 3: Manual Methods vs. Modern Science: The Great Workflow Debate

Third try. Third failure. The fume hood is running. The xylene smells terrible. And the protocol that worked last Tuesday is giving nothing but debris. Sound familiar? Here's the question nobody was asking: Is it your technique—or is it the physics?
[Read Blog](/resources/unlocking-ffpe-archives-part-3-manual-vs-modern-workflow-debate/) [Blog Part 4](/resources/unlocking-ffpe-archives-part-4-two-hours-sixty-minutes-automation/) Singulator 200+
### Unlocking FFPE Archives - Part 4: From Two Hours to Sixty Minutes: What Automation Actually Changes

What if that two-hour protocol took sixty minutes? What if twelve pipetting steps dropped to four? What if the fume hood became optional? These aren't hypotheticals. This is what purpose-built automation looks like. And the difference isn't just time.
[Read Blog](/resources/unlocking-ffpe-archives-part-4-two-hours-sixty-minutes-automation/) [Blog Part 5](/resources/unlocking-ffpe-archives-part-5-the-archive-opens-are-you-ready/) Singulator 200+
### Unlocking FFPE Archives - Part 5: The Archive Opens: Are You Ready?

Behind every tissue block is a patient who said yes. Yes to collection. Yes to research. Yes to the hope that their gift might help someone else. They trusted the science. The question now: are the protocols worthy of that trust?
[Read Blog](/resources/unlocking-ffpe-archives-part-5-the-archive-opens-are-you-ready/) [Publication](https://www.biorxiv.org/content/10.1101/2025.03.13.643011v2) Singulator 100
### Spatial Transcriptomics and Single-Nucleus RNA Sequencing Reveal rAAV2- and rAAV9-Specific Transduction Signatures in the Mouse Liver
[View Publication](https://www.biorxiv.org/content/10.1101/2025.03.13.643011v2) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12345466/) Singulator 100
### Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal Cellular Heterogeneity and Intercellular Communication Networks in the Hypothalamus-Pituitary-Ovarian Axis of Pregnant Mongolian Cattle
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12345466/) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12259082/) Singulator 200+
### Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12259082/) [Publication](https://www.nature.com/articles/s44161-025-00698-y) Singulator 100
### Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis
[View Publication](https://www.nature.com/articles/s44161-025-00698-y) [Publication](https://www.biorxiv.org/content/10.1101/2025.06.25.661527v1) Singulator 100
### A porcine germ cell depletion model to investigate the role of germ cells in gonadal development
[View Publication](https://www.biorxiv.org/content/10.1101/2025.06.25.661527v1) [Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_final_v1.pdf) Singulator 200+
### Brochure - Singulator 200+
[Download Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_final_v1.pdf) [Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_FFPE_final_v1.pdf) Singulator 200+
### Brochure - S200+ - FFPE
[Download Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_FFPE_final_v1.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/11/Applicaiton_Note_Singulator_FFPE_v1_11-30-25.pdf) Singulator 200+
### FFPE Tissue Dissociation
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/11/Applicaiton_Note_Singulator_FFPE_v1_11-30-25.pdf) [Blog Part 3](/resources/brain-map-part-3-fresh-vs-frozen-which-side-are-you-on/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 3: Fresh vs. Frozen: Which Side Are You On?

Fresh vs. Frozen: Which Side Are You On? Description: The debate between fresh tissue (whole cells) and frozen tissue (nuclei) divides labs. We explore why fresh dissociation often creates a "map of a disaster" through stress artifacts, and why frozen nuclei offer the unbiased, stable truth required for atlas-scale science.
[Read Blog](/resources/brain-map-part-3-fresh-vs-frozen-which-side-are-you-on/) [Blog Part 4](/resources/brain-map-part-4-the-list-is-good-but-is-the-map-better/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 4: The List is Good, But Is the Map Better?

The List is Good, But Is the Map Better? Description: Single-nucleus sequencing gives you the "List" of cell types, but Spatial Transcriptomics gives you the "Map." Discover how combining these technologies creates a high-resolution "Precision Point," and how one automated platform can serve as the engine for both workflows.
[Read Blog](/resources/brain-map-part-4-the-list-is-good-but-is-the-map-better/) [Blog Part 5](/resources/brain-map-part-5-the-journey-ends-here-are-you-ready-to-build-the-map/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 5: The Journey Ends Here - Are You Ready to Build the Map?

From the hidden world of glia to the final 3D atlas, the journey of modern neuroscience relies on one foundational step: sample preparation. We conclude our series by challenging researchers to prioritize clean, reproducible input to build the definitive map of the human brain.
[Read Blog](/resources/brain-map-part-5-the-journey-ends-here-are-you-ready-to-build-the-map/) [Blog Part 1](/resources/brain-map-part-1-why-did-science-miss-half-the-brain/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 1: Why Did Science Miss Half the Brain?

For a century, neuroscience focused exclusively on the neuron, dismissing glia as mere "packing peanuts." Discover how single-nucleus sequencing revealed the active, critical role of the brain's immune and support systems—and why this shift changes everything for Alzheimer's research.
[Read Blog](/resources/brain-map-part-1-why-did-science-miss-half-the-brain/) [Blog Part 2](/resources/brain-map-part-2-what-is-ruining-your-frozen-experiments/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 2: What is Ruining Your Frozen Experiments?

What is Ruining Your Frozen Experiments? Description: Every great story needs a villain. In frozen brain tissue processing, that villain is myelin debris. Learn how lipid contamination clogs microfluidics and ruins data, and see how the Singulator’s automated Protocol DP0006 neutralizes this threat to unlock biobank archives.
[Read Blog](/resources/brain-map-part-2-what-is-ruining-your-frozen-experiments/) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/11/2025-11-05_Precision-Cell-Systems_-Automating-Tissue-Dissociation-for-Single-Cell-Analysis.mp4) Singulator 100 Singulator 200
### Webinar 11-5-25: Automating Tissue Dissociation for Single Cell Analysis
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/11/2025-11-05_Precision-Cell-Systems_-Automating-Tissue-Dissociation-for-Single-Cell-Analysis.mp4) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/Research-Spotlight-Optimizing-Nuclei-Isolation-for-Reliable-snRNA-seq-A-Comparative-Study-Validates-the-SingulatorTM-Platform.pdf) Singulator 100 Singulator 200
### Optimizing Nuclei Isolation for Reliable snRNA-seq - A Comparative Study Validates the Singulator Platform
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/Research-Spotlight-Optimizing-Nuclei-Isolation-for-Reliable-snRNA-seq-A-Comparative-Study-Validates-the-SingulatorTM-Platform.pdf) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC11974938/) Singulator 100 Singulator 200
### Comparative analysis of nuclei isolation methods for brain single-nucleus RNA sequencing
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC11974938/) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-III.mp4) Singulator 100 Singulator 200
### Singulator Sessions III: Unlock the Potential of Your Neuroscience Samples with the Singulator Platform Singulator Session III
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-III.mp4) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-II-Oncology-Applications.mp4) Singulator 100 Singulator 200
### Singulator Sessions II: Leveraging the Singulator Platform for Oncology Applications
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-II-Oncology-Applications.mp4) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-I.mp4) Singulator 100 Singulator 200
### Singulator Session I: Automating Tissue Dissociation for Single-Cell Analysis
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-I.mp4) [Publication](https://precisioncellsystems.com/wp-content/uploads/2025/10/s41586-022-05450-1.pdf) Singulator 100 Singulator 200
### Kinase signaling in excitatory neurons regulates sleep quantity and depth
[View Publication](https://precisioncellsystems.com/wp-content/uploads/2025/10/s41586-022-05450-1.pdf) [Publication](https://www.biorxiv.org/content/10.1101/2023.09.11.557118v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.28.1743558253016&__hsfp=1300058700&submissionGuid=f991745a-6dc4-444a-8d60-f34230c118e0) Singulator 100 Singulator 200
### Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics
[View Publication](https://www.biorxiv.org/content/10.1101/2023.09.11.557118v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.28.1743558253016&__hsfp=1300058700&submissionGuid=f991745a-6dc4-444a-8d60-f34230c118e0) [Publication](https://www.science.org/doi/10.1126/scitranslmed.abq0476?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.30.1743558253016&__hsfp=1300058700&submissionGuid=1bb5f085-dcf1-4a34-a999-052cc6cad242) Singulator 100 Singulator 200
### Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse
[View Publication](https://www.science.org/doi/10.1126/scitranslmed.abq0476?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.30.1743558253016&__hsfp=1300058700&submissionGuid=1bb5f085-dcf1-4a34-a999-052cc6cad242) [Publication](https://link.springer.com/article/10.1007/s00401-023-02604-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.31.1743558253016&__hsfp=1300058700&submissionGuid=c7f3c611-02ec-4ec0-a180-2e24c56a4025) Singulator 100 Singulator 200
### Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy
[View Publication](https://link.springer.com/article/10.1007/s00401-023-02604-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.31.1743558253016&__hsfp=1300058700&submissionGuid=c7f3c611-02ec-4ec0-a180-2e24c56a4025) [Publication](https://www.nature.com/articles/s41467-023-36344-z?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.33.1743558253016&__hsfp=1300058700&submissionGuid=287fece2-b893-47b1-82f8-69ed503994a0) Singulator 100 Singulator 200
### Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer
[View Publication](https://www.nature.com/articles/s41467-023-36344-z?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.33.1743558253016&__hsfp=1300058700&submissionGuid=287fece2-b893-47b1-82f8-69ed503994a0) [Publication](https://elifesciences.org/articles/81090?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.27.1743558253016&__hsfp=1300058700&submissionGuid=d621ffa4-d176-4293-828a-2ca2f3c1f2e6) Singulator 100 Singulator 200
### Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19
[View Publication](https://elifesciences.org/articles/81090?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.27.1743558253016&__hsfp=1300058700&submissionGuid=d621ffa4-d176-4293-828a-2ca2f3c1f2e6) [Publication](https://www.biorxiv.org/content/10.1101/2023.11.17.567534v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.26.1743558253016&__hsfp=1300058700&submissionGuid=838128d8-35f7-458b-a0a0-6e5e93506818) Singulator 100 Singulator 200
### Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
[View Publication](https://www.biorxiv.org/content/10.1101/2023.11.17.567534v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.26.1743558253016&__hsfp=1300058700&submissionGuid=838128d8-35f7-458b-a0a0-6e5e93506818) [Presentation](https://sail.mskcc.org/research/experimental-research/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.1.1743114390284&__hsfp=1300058700&submissionGuid=da42544b-9315-47f8-87f4-f27614a8159e) Singulator 100 Singulator 200
### Comparison of polydT and probe-based RNA capture for single-cell RNAseq
[View Presentation](https://sail.mskcc.org/research/experimental-research/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.1.1743114390284&__hsfp=1300058700&submissionGuid=da42544b-9315-47f8-87f4-f27614a8159e) [Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-meniscus-for-10x-multi-eq2lyweqwvx9/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.3.1743114390284&__hsfp=1300058700&submissionGuid=4b05fc85-7463-4780-a2b2-ffab27dfab93) Singulator 100 Singulator 200
### Nuclei Isolation from Human Meniscus for 10x Multiome
[Read Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-meniscus-for-10x-multi-eq2lyweqwvx9/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.3.1743114390284&__hsfp=1300058700&submissionGuid=4b05fc85-7463-4780-a2b2-ffab27dfab93) [Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-synovium-and-infrapate-ewov193molr2/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.1.1743120525713&__hsfp=1300058700&submissionGuid=b0e5a9f5-043f-4bd6-aed3-b4f40dec0679) Singulator 100 Singulator 200
### Nuclei Isolation from Human Synovium and Infrapatellar Fat Pad for 10x Multiome
[Read Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-synovium-and-infrapate-ewov193molr2/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.1.1743120525713&__hsfp=1300058700&submissionGuid=b0e5a9f5-043f-4bd6-aed3-b4f40dec0679) [Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-cartilage-for-10x-mult-rm7vzj7q5lx1/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.2.1743120525713&__hsfp=1300058700&submissionGuid=de8f645d-64af-4162-9628-0577ae4400f2) Singulator 100 Singulator 200
### Nuclei Isolation from Human Cartilage for 10x Multiome
[Read Protocol](https://www.protocols.io/view/nuclei-isolation-from-human-cartilage-for-10x-mult-rm7vzj7q5lx1/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.2.1743120525713&__hsfp=1300058700&submissionGuid=de8f645d-64af-4162-9628-0577ae4400f2) [Protocol](https://www.protocols.io/view/1-perff-seq-cell-and-nuclei-preparation-c8n3zvgn.html?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.3.1743120525713&__hsfp=1300058700&submissionGuid=cb652c05-65bb-4462-94bc-f6d6270950ee) Singulator 200+
### PERFF-seq: Cell and Nuclei Preparation
[Read Protocol](https://www.protocols.io/view/1-perff-seq-cell-and-nuclei-preparation-c8n3zvgn.html?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.3.1743120525713&__hsfp=1300058700&submissionGuid=cb652c05-65bb-4462-94bc-f6d6270950ee) [Protocol](https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.848?__hsfp=1300058700&__hssc=225964101.4.1743120525713&__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&submissionGuid=51d58e6d-a114-45fd-a519-2d936a8859b0) Singulator 100 Singulator 200
### Systematic Sampling of the Female Reproductive System for Molecular Characterization
[Read Protocol](https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.848?__hsfp=1300058700&__hssc=225964101.4.1743120525713&__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&submissionGuid=51d58e6d-a114-45fd-a519-2d936a8859b0) [Protocol](https://www.jove.com/t/65611/a-simple-quick-partially-automated-protocol-for-isolation-single?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.6.1743120525713&__hsfp=1300058700&submissionGuid=d251dea3-f5b9-441b-b0eb-4eadf390de7e) Singulator 100 Singulator 200
### A Simple, Quick, and Partially Automated Protocol for the Isolation of Single Nuclei from Frozen Mammalian Tissues for Single Nucleus Sequencing
[Read Protocol](https://www.jove.com/t/65611/a-simple-quick-partially-automated-protocol-for-isolation-single?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.6.1743120525713&__hsfp=1300058700&submissionGuid=d251dea3-f5b9-441b-b0eb-4eadf390de7e) [Protocol](https://www.protocols.io/view/nuclei-extraction-for-single-cell-rnaseq-from-froz-q26g74xzqgwz/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.13.1743120525713&__hsfp=1300058700&submissionGuid=cc1fb887-2fc0-423d-9124-6e7264b1d55f) Singulator 100 Singulator 200
### Nuclei extraction for single-cell RNAseq from frozen tissue using Singulator™ 100
[Read Protocol](https://www.protocols.io/view/nuclei-extraction-for-single-cell-rnaseq-from-froz-q26g74xzqgwz/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.13.1743120525713&__hsfp=1300058700&submissionGuid=cc1fb887-2fc0-423d-9124-6e7264b1d55f) [Protocol](https://www.protocols.io/view/tissue-dissociation-for-multiome-analysis-using-s2-yxmvmndx6g3p/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.14.1743120525713&__hsfp=1300058700&submissionGuid=8ee42fe6-6ea0-48eb-bbd2-8bdaf97d156b) Singulator 100 Singulator 200
### Tissue Dissociation for Multiome Analysis Using S2 Singulator
[Read Protocol](https://www.protocols.io/view/tissue-dissociation-for-multiome-analysis-using-s2-yxmvmndx6g3p/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.14.1743120525713&__hsfp=1300058700&submissionGuid=8ee42fe6-6ea0-48eb-bbd2-8bdaf97d156b) [Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-v3-in-mouse-lymph-node-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.5.1743120525713&__hsfp=1300058700&submissionGuid=ccd705a7-ba96-482f-b624-df6abb8a7201) Singulator 100 Singulator 200
### Parse Biosciences: Performance of Evercode™ WT in Mouse Lymph Node
[View Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-v3-in-mouse-lymph-node-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.5.1743120525713&__hsfp=1300058700&submissionGuid=ccd705a7-ba96-482f-b624-df6abb8a7201) [Data Set](https://www.parsebiosciences.com/datasets/lung/performance-of-evercode-wt-in-mouse-lung-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.15.1743120525713&__hsfp=1300058700&submissionGuid=9634964b-b524-4b31-9aa1-f4d35dbada04) Singulator 100 Singulator 200
### Parse Biosciences: Performance of Evercode™ WT in Mouse Lung Nuclei
[View Data Set](https://www.parsebiosciences.com/datasets/lung/performance-of-evercode-wt-in-mouse-lung-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.15.1743120525713&__hsfp=1300058700&submissionGuid=9634964b-b524-4b31-9aa1-f4d35dbada04) [Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-in-mouse-kidney-cells/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.16.1743120525713&__hsfp=1300058700&submissionGuid=07d1b598-d2a7-4804-bf9d-fb8f317d8d10) Singulator 100 Singulator 200
### Parse Biosciences: Performance of Evercode™ WT in Mouse Kidney Cells - 2
[View Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-in-mouse-kidney-cells/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.16.1743120525713&__hsfp=1300058700&submissionGuid=07d1b598-d2a7-4804-bf9d-fb8f317d8d10) [Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-in-mouse-kidney-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.17.1743120525713&__hsfp=1300058700&submissionGuid=4fb6fdf7-f4f1-4da0-a5ba-a82428f174e0) Singulator 100 Singulator 200
### Parse Biosciences: Performance of Evercode™ WT in Mouse Kidney Nuclei
[View Data Set](https://www.parsebiosciences.com/datasets/performance-of-evercode-wt-in-mouse-kidney-nuclei/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.17.1743120525713&__hsfp=1300058700&submissionGuid=4fb6fdf7-f4f1-4da0-a5ba-a82428f174e0) [Data Set](https://www.parsebiosciences.com/datasets/skin/performance-of-evercode-wt-in-mouse-skin-cells/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.18.1743120525713&__hsfp=1300058700&submissionGuid=c1dab13d-ab5d-4618-b08c-39d416e1c057) Singulator 100 Singulator 200
### Parse Biosciences: Performance of Evercode™ WT in Mouse Skin Cells
[View Data Set](https://www.parsebiosciences.com/datasets/skin/performance-of-evercode-wt-in-mouse-skin-cells/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.18.1743120525713&__hsfp=1300058700&submissionGuid=c1dab13d-ab5d-4618-b08c-39d416e1c057) [Publication](https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00484-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.1.1743558253016&__hsfp=1300058700&submissionGuid=8e58a180-37fa-4d55-a17c-1d7954a03932) Singulator 100 Singulator 200
### Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
[View Publication](https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00484-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.1.1743558253016&__hsfp=1300058700&submissionGuid=8e58a180-37fa-4d55-a17c-1d7954a03932) [Publication](https://www.biorxiv.org/content/10.1101/2024.12.31.630834v1.full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.2.1743558253016&__hsfp=1300058700&submissionGuid=a17e7378-367f-4fd1-9baa-242deedc0beb) Singulator 100 Singulator 200
### Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function
[View Publication](https://www.biorxiv.org/content/10.1101/2024.12.31.630834v1.full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.2.1743558253016&__hsfp=1300058700&submissionGuid=a17e7378-367f-4fd1-9baa-242deedc0beb) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12276987/) Singulator 200+
### Transcript-specific enrichment enables profiling rare cell states via scRNA-seq
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12276987/) [Publication](https://www.nature.com/articles/s41598-024-82736-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.4.1743558253016&__hsfp=1300058700&submissionGuid=30d7cb64-704f-4415-aa48-4016d429e620#Sec9) Singulator 100 Singulator 200
### High-throughput gene expression analysis with TempO-LINC sensitively resolves complex brain, lung and kidney heterogeneity at single-cell resolution
[View Publication](https://www.nature.com/articles/s41598-024-82736-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.4.1743558253016&__hsfp=1300058700&submissionGuid=30d7cb64-704f-4415-aa48-4016d429e620#Sec9) [Publication](https://www.biorxiv.org/content/10.1101/2024.12.01.626270v1.full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.5.1743558253016&__hsfp=1300058700&submissionGuid=4cb56fc6-168a-4dd5-a3f8-8afaf354c848) Singulator 100 Singulator 200
### Multi-omic profiling identifies malignant subpopulations and a hypoxia-driven angiogenic axis as therapeutic vulnerabilities in sinonasal squamous cell carcinoma
[View Publication](https://www.biorxiv.org/content/10.1101/2024.12.01.626270v1.full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.5.1743558253016&__hsfp=1300058700&submissionGuid=4cb56fc6-168a-4dd5-a3f8-8afaf354c848) [Publication](https://www.researchsquare.com/article/rs-5454144/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.6.1743558253016&__hsfp=1300058700&submissionGuid=cd9523ee-14ab-4574-8764-46924d882604) Singulator 100 Singulator 200
### Identification of specific microbiota members that induce beige fat biogenesis in response to dietary cues
[View Publication](https://www.researchsquare.com/article/rs-5454144/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.6.1743558253016&__hsfp=1300058700&submissionGuid=cd9523ee-14ab-4574-8764-46924d882604) [Publication](https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00661-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580724006610%3Fshowall%3Dtrue) Singulator 100 Singulator 200
### Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility
[View Publication](https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00661-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580724006610%3Fshowall%3Dtrue) [Publication](https://aacrjournals.org/cancerres/article/85/2/231/750993/FOXR2-Targets-LHX6-DLX-Neural-Lineages-to-Drive) Singulator 100 Singulator 200
### FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma
[View Publication](https://aacrjournals.org/cancerres/article/85/2/231/750993/FOXR2-Targets-LHX6-DLX-Neural-Lineages-to-Drive) [Publication](https://www.nature.com/articles/s43018-024-00838-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.9.1743558253016&__hsfp=1300058700&submissionGuid=b7f7a640-05da-4d4a-bac8-9f4b8daf751a) Singulator 100 Singulator 200
### The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
[View Publication](https://www.nature.com/articles/s43018-024-00838-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.9.1743558253016&__hsfp=1300058700&submissionGuid=b7f7a640-05da-4d4a-bac8-9f4b8daf751a) [Publication](https://www.biorxiv.org/content/10.1101/2024.09.19.613680v2?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.10.1743558253016&__hsfp=1300058700&submissionGuid=fefae69e-e5ef-46cc-94e1-7f2a6872a7d6) Singulator 100 Singulator 200
### High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells
[View Publication](https://www.biorxiv.org/content/10.1101/2024.09.19.613680v2?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.10.1743558253016&__hsfp=1300058700&submissionGuid=fefae69e-e5ef-46cc-94e1-7f2a6872a7d6) [Publication](https://www.cell.com/iscience/fulltext/S2589-0042(24)01885-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.11.1743558253016&__hsfp=1300058700&_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224018856%3Fshowall%3Dtrue&submissionGuid=5f59d348-29e9-4a93-b2fe-e4b9982c32a7) Singulator 100 Singulator 200
### Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses
[View Publication](https://www.cell.com/iscience/fulltext/S2589-0042(24)01885-6?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.11.1743558253016&__hsfp=1300058700&_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224018856%3Fshowall%3Dtrue&submissionGuid=5f59d348-29e9-4a93-b2fe-e4b9982c32a7) [Publication](https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1444100/full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.12.1743558253016&__hsfp=1300058700&submissionGuid=d76f90fe-216c-4aac-b313-7231a43c8a13) Singulator 100 Singulator 200
### Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis
[View Publication](https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1444100/full?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.12.1743558253016&__hsfp=1300058700&submissionGuid=d76f90fe-216c-4aac-b313-7231a43c8a13) [Publication](https://www.biorxiv.org/content/10.1101/2024.08.05.606414v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.13.1743558253016&__hsfp=1300058700&submissionGuid=4e193d20-31b9-412c-b6f3-b7bd9b02f3d5) Singulator 100 Singulator 200
### A single-nucleus census of immune and non-immune cell types for the major immune organ systems of chicken
[View Publication](https://www.biorxiv.org/content/10.1101/2024.08.05.606414v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.13.1743558253016&__hsfp=1300058700&submissionGuid=4e193d20-31b9-412c-b6f3-b7bd9b02f3d5) [Publication](https://www.biorxiv.org/content/10.1101/2024.08.03.605165v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.14.1743558253016&__hsfp=1300058700&submissionGuid=6f666125-4b9b-40ae-a7f3-013cd588958f) Singulator 100 Singulator 200
### Genomic evolution of pancreatic cancer at single-cell resolution
[View Publication](https://www.biorxiv.org/content/10.1101/2024.08.03.605165v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.14.1743558253016&__hsfp=1300058700&submissionGuid=6f666125-4b9b-40ae-a7f3-013cd588958f) [Publication](https://www.nature.com/articles/s41467-024-50660-y?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.15.1743558253016&__hsfp=1300058700&submissionGuid=a9fd91da-313a-4951-8e1d-95d0cf38654f) Singulator 100 Singulator 200
### A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma
[View Publication](https://www.nature.com/articles/s41467-024-50660-y?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.15.1743558253016&__hsfp=1300058700&submissionGuid=a9fd91da-313a-4951-8e1d-95d0cf38654f) [Publication](https://www.cell.com/iscience/fulltext/S2589-0042(24)01875-3?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.16.1743558253016&__hsfp=1300058700&_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224018753%3Fshowall%3Dtrue&submissionGuid=5f182724-82b6-411b-bfa0-2bf14f4c64f3) Singulator 100 Singulator 200
### Single-cell landscape of long and short glandular trichomes in Nicotiana tabacum leaves
[View Publication](https://www.cell.com/iscience/fulltext/S2589-0042(24)01875-3?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.16.1743558253016&__hsfp=1300058700&_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224018753%3Fshowall%3Dtrue&submissionGuid=5f182724-82b6-411b-bfa0-2bf14f4c64f3) [Publication](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064719?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.17.1743558253016&__hsfp=1300058700&submissionGuid=b4207542-bea7-4f83-82ee-adae95b7ce4b) Singulator 100 Singulator 200
### Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
[View Publication](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064719?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.17.1743558253016&__hsfp=1300058700&submissionGuid=b4207542-bea7-4f83-82ee-adae95b7ce4b) [Publication](https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00628-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.18.1743558253016&__hsfp=1300058700&submissionGuid=ab722450-c4b5-4fb8-9824-6d715a4fe27d) Singulator 100 Singulator 200
### Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
[View Publication](https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00628-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.18.1743558253016&__hsfp=1300058700&submissionGuid=ab722450-c4b5-4fb8-9824-6d715a4fe27d) [Publication](https://www.biorxiv.org/content/10.1101/2024.07.03.601895v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.19.1743558253016&__hsfp=1300058700&submissionGuid=9c9dd609-839a-4835-bdfe-9a55a15ddfab) Singulator 100 Singulator 200
### An orbitocortical-thalamic circuit suppresses binge alcohol-drinking
[View Publication](https://www.biorxiv.org/content/10.1101/2024.07.03.601895v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.19.1743558253016&__hsfp=1300058700&submissionGuid=9c9dd609-839a-4835-bdfe-9a55a15ddfab) [Publication](https://www.biorxiv.org/content/10.1101/2024.06.27.601103v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.20.1743558253016&__hsfp=1300058700&submissionGuid=dfdb8bf0-7f4d-4b64-909b-c4678cd4b48c) Singulator 100 Singulator 200
### Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia
[View Publication](https://www.biorxiv.org/content/10.1101/2024.06.27.601103v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.20.1743558253016&__hsfp=1300058700&submissionGuid=dfdb8bf0-7f4d-4b64-909b-c4678cd4b48c) [Publication](https://www.biorxiv.org/content/10.1101/2024.05.22.595241v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.21.1743558253016&__hsfp=1300058700&submissionGuid=aa6eed6f-a4ec-4d76-bc84-dd7e2fc0fe73) Singulator 100 Singulator 200
### Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts
[View Publication](https://www.biorxiv.org/content/10.1101/2024.05.22.595241v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.21.1743558253016&__hsfp=1300058700&submissionGuid=aa6eed6f-a4ec-4d76-bc84-dd7e2fc0fe73) [Publication](https://www.biorxiv.org/content/10.1101/2024.07.01.601334v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.22.1743558253016&__hsfp=1300058700&submissionGuid=3a510c1b-ea13-4041-84cf-21b9345137b2) Singulator 100 Singulator 200
### Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic NF1 mutant glioblastoma
[View Publication](https://www.biorxiv.org/content/10.1101/2024.07.01.601334v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.22.1743558253016&__hsfp=1300058700&submissionGuid=3a510c1b-ea13-4041-84cf-21b9345137b2) [Publication](https://www.biorxiv.org/content/10.1101/2024.04.26.587806v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.23.1743558253016&__hsfp=1300058700&ct=&submissionGuid=2ff5c384-7040-4df8-91c6-30eaae489b4f) Singulator 100 Singulator 200
### High-resolution detection of copy number alterations in single cells with HiScanner
[View Publication](https://www.biorxiv.org/content/10.1101/2024.04.26.587806v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.23.1743558253016&__hsfp=1300058700&ct=&submissionGuid=2ff5c384-7040-4df8-91c6-30eaae489b4f) [Publication](https://www.nature.com/articles/s41587-024-02193-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.24.1743558253016&__hsfp=1300058700&submissionGuid=d4eb5dac-02d7-45d8-953c-6c79fc38c05f) Singulator 200+
### The covariance environment defines cellular niches for spatial inference
[View Publication](https://www.nature.com/articles/s41587-024-02193-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.24.1743558253016&__hsfp=1300058700&submissionGuid=d4eb5dac-02d7-45d8-953c-6c79fc38c05f) [Publication](https://www.science.org/doi/10.1126/sciadv.adn4649?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.25.1743558253016&__hsfp=1300058700&submissionGuid=7cb6bf68-0d64-411b-96de-7235ff6475e4) Singulator 100 Singulator 200
### Childhood cancer mutagenesis caused by transposase-derived PGBD5
[View Publication](https://www.science.org/doi/10.1126/sciadv.adn4649?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.25.1743558253016&__hsfp=1300058700&submissionGuid=7cb6bf68-0d64-411b-96de-7235ff6475e4) [Publication](https://www.biorxiv.org/content/10.1101/2023.08.19.553427v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.29.1743558253016&__hsfp=1300058700&ct=&submissionGuid=a4f220b8-1b13-4953-9b56-b675ed8faf9a) Singulator 100 Singulator 200
### Neuronal SNCA transcription during Lewy body formation
[View Publication](https://www.biorxiv.org/content/10.1101/2023.08.19.553427v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.29.1743558253016&__hsfp=1300058700&ct=&submissionGuid=a4f220b8-1b13-4953-9b56-b675ed8faf9a) [Publication](https://www.sciencedirect.com/science/article/pii/S0092867423001666?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.32.1743558253016&__hsfp=1300058700&submissionGuid=14a4fa98-f109-4563-98aa-4aa9ea18fe6b) Singulator 100 Singulator 200
### Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
[View Publication](https://www.sciencedirect.com/science/article/pii/S0092867423001666?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.32.1743558253016&__hsfp=1300058700&submissionGuid=14a4fa98-f109-4563-98aa-4aa9ea18fe6b) [Publication](https://www.aging-us.com/article/204435?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.34.1743558253016&__hsfp=1300058700&submissionGuid=c677f79d-e8f0-4d9f-b7f5-3458555fa9db) Singulator 100 Singulator 200
### Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
[View Publication](https://www.aging-us.com/article/204435?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.34.1743558253016&__hsfp=1300058700&submissionGuid=c677f79d-e8f0-4d9f-b7f5-3458555fa9db) [Publication](https://www.nature.com/articles/s41588-022-01205-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.36.1743558253016&__hsfp=1300058700&submissionGuid=16d6bd6f-42f1-45ab-b755-85d2fc136d9a) Singulator 100 Singulator 200
### K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
[View Publication](https://www.nature.com/articles/s41588-022-01205-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.36.1743558253016&__hsfp=1300058700&submissionGuid=16d6bd6f-42f1-45ab-b755-85d2fc136d9a) [Publication](https://www.nature.com/articles/s41588-022-01088-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.37.1743558253016&__hsfp=1300058700&submissionGuid=a2d222b9-a609-4fd0-a304-be6a34ec2362) Singulator 100 Singulator 200
### Single-cell analyses reveal a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer
[View Publication](https://www.nature.com/articles/s41588-022-01088-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.37.1743558253016&__hsfp=1300058700&submissionGuid=a2d222b9-a609-4fd0-a304-be6a34ec2362)
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