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# Neuroscience Resources
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[Field Guide](/resources/brain-tissue-complexity-myelin-lipids-neuronal-nuclei/) Singulator 200+
### Overcoming Brain Tissue Complexity: Myelin, Lipids, and Fragile Neuronal Nuclei

Brain FFPE tissue creates unique nuclei isolation challenges. Myelin debris, lipid contamination, and fragile neuronal nuclei require controlled automated processing to preserve cell-type diversity for single-nucleus sequencing.
[Read Field Guide](/resources/brain-tissue-complexity-myelin-lipids-neuronal-nuclei/) [Field Guide](/resources/brain-tumor-ffpe-surgical-resection-single-cell/) Singulator 200+
### Brain Tumor FFPE Processing: From Surgical Resection to Single-Nucleus Insights

Process brain tumor FFPE from surgical resections on the Singulator 200+. Preserve cancer cells and immune populations for snRNA-seq and spatial analysis.
[Read Field Guide](/resources/brain-tumor-ffpe-surgical-resection-single-cell/) [Ebook](/resources/cold-case-files-neuroscience-ffpe/) Singulator 200+
### Cold Case Files:The Brain's Embedded Evidence

How the Singulator 200+ preserves fragile neuronal nuclei from irreplaceable postmortem brain tissue. Automated FFPE processing for Alzheimer's, brain tumors, and brain atlases.
[Read Ebook](/resources/cold-case-files-neuroscience-ffpe/) [Field Guide](/resources/ffpe-neurodegenerative-disease-research-singulator/) Singulator 200+
### FFPE Nuclei Extraction for Neurodegenerative Disease Research

Extract nuclei from FFPE brain tissue for Alzheimer's, Parkinson's, and Lewy body research. Longitudinal cohorts, cell-type preservation, and disease staging on the Singulator 200+.
[Read Field Guide](/resources/ffpe-neurodegenerative-disease-research-singulator/) [Field Guide](/resources/integrating-snrna-seq-spatial-transcriptomics-brain-ffpe/) Singulator 200+
### Integrating snRNA-seq with spatial transcriptomics for brain mapping

Pair spatial transcriptomics with snRNA-seq from the same FFPE brain block. Block allocation, platform selection, and nuclei quality for multi-omic brain studies.
[Read Field Guide](/resources/integrating-snrna-seq-spatial-transcriptomics-brain-ffpe/) [Field Guide](/resources/maximizing-limited-brain-tissue-sections-ffpe/) Singulator 200+
### Maximizing Results from Limited Brain Tissue Sections

Get high-quality nuclei from limited postmortem brain FFPE sections. Process NIH biobank allocations, hospital archives, and surgical specimens on the Singulator 200+.
[Read Field Guide](/resources/maximizing-limited-brain-tissue-sections-ffpe/) [Field Guide](/resources/navigating-postmortem-brain-tissue-ffpe-genomics/) Singulator 200+
### Navigating postmortem brain tissue for FFPE genomics

Practical guide to postmortem brain FFPE challenges: necropsy timing, fixation variability, biobank sourcing, myelin debris, and how the Singulator 200+ standardizes nuclei extraction.
[Read Field Guide](/resources/navigating-postmortem-brain-tissue-ffpe-genomics/) [Field Guide](/resources/reproducible-multi-site-brain-tissue-atlases-singulator/) Singulator 200+
### Building Reproducible Multi-Site Brain Tissue Atlases

Standardize brain FFPE nuclei extraction across consortium sites with the Singulator 200+. Eliminate operator variability, prevent batch effects, and scale for atlas projects.
[Read Field Guide](/resources/reproducible-multi-site-brain-tissue-atlases-singulator/) [Blog Part 5](/resources/cold-case-closed-brain-atlas/) Singulator 200+
### Cold Case - Part 5: Case Closed

Brain atlases are being built. Archival tissue is finally talking. How standardized nuclei extraction and platform-agnostic analysis are solving neuroscience's oldest cold cases.
[Read Blog](/resources/cold-case-closed-brain-atlas/) [Blog Part 2](/resources/cold-case-contaminated-evidence-brain-tissue/) Singulator 200+
### Cold Case - Part 2: Contaminated Evidence

Manual extraction of nuclei from FFPE brain tissue destroys 50 to 60 percent of starting material. Fragile neurons die first, leaving biased results. Here is what goes wrong.
[Read Blog](/resources/cold-case-contaminated-evidence-brain-tissue/) [Blog Part 1](/resources/cold-case-files-brain-tissue-evidence/) Singulator 200+
### Cold Case - Part 1: The Cold Case Files

Millions of FFPE brain tissue blocks sit in biobanks worldwide, holding decades of evidence about Alzheimer's, Parkinson's, and neurodegenerative diseases. What if we could reopen these cases?
[Read Blog](/resources/cold-case-files-brain-tissue-evidence/) [Blog Part 4](/resources/cold-case-forensic-lab-singulator-200-plus/) Singulator 200+
### Cold Case - Part 4: The Forensic Lab

Manual FFPE processing destroys fragile neuronal nuclei and produces variable results. The Singulator 200+ automates the workflow with a two-cartridge system that delivers consistent, operator-independent results from irreplaceable brain tissue.
[Read Blog](/resources/cold-case-forensic-lab-singulator-200-plus/) [Blog Part 3](/resources/cold-case-one-shot-at-the-scene/) Singulator 200+
### Cold Case - Part 3: One Shot at the Scene

NIH biobanks give you one allocation of irreplaceable brain tissue. Manual processing destroys 50-60% before analysis begins. The extraction method is the real variable.
[Read Blog](/resources/cold-case-one-shot-at-the-scene/) [Ebook](/resources/tissue-dissociation-protocol-guide/) Singulator 100 Singulator 200 Singulator 200+
### Tissue Dissociation Guide

The most comprehensive tissue dissociation reference available. Interactive protocols for single-cell isolation and nuclei extraction across 57+ tissue types with community and Singulator-optimized methods.
[Read Ebook](/resources/tissue-dissociation-protocol-guide/) [Publication](https://doi.org/10.64898/2026.01.16.699996) Moxi GO II
### Seasonal blood-brain barrier plasticity links environmental cues to migratory behavior in monarch butterflies

The authors used a Moxi GO II to measure viability and concentration of dissociated monarch brain single-cell suspensions immediately before 10X Genomics single-cell capture for scRNA-seq.
[View Publication](https://doi.org/10.64898/2026.01.16.699996) [App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Nuclei-Sequencing-of-Mouse-Cerebellum.pdf) Singulator 100 Singulator 200
### Single-Nuclei Sequencing of Mouse Cerebellum with 10x

The Singulator™ Platform provides a reproducible and precise method for isolating nuclei from
complex tissues suitable for single-nuclei RNA sequencing. Our results demonstrate consistent nuclei
yield and high-quality sequencing metrics across biological replicates, making it a reliable tool
for neuroscientific research. The ability to produce high-quality nuclei with minimal variability
enhances the accuracy of downstream snRNA analyses, facilitating deeper insights into normal biology
and disease. Finally, the ability to identify rare cell types underscores the efficacy of the
Singulator Platform in comprehensive cellular analysis, providing a detailed representation of the
cellular landscape.
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2026/03/Singulator-Application-Note-Single-Nuclei-Sequencing-of-Mouse-Cerebellum.pdf) [Field Guide](/resources/02-ai-segmentation-failures/)
### AI Segmentation Failures

AI segmentation algorithms fail when encountering debris, clusters, or samples they were not trained on—resulting in minimum 3-4% error per image even under.
[Read Field Guide](/resources/02-ai-segmentation-failures/) [Publication](https://pubmed.ncbi.nlm.nih.gov/40236205/) Moxi Z
### CHD7 binds distinct regions in the Sox11 locus to regulate neuronal differentiation

In this study, the authors used Moxi to standardize plated cell numbers and per-reaction cell inputs for proliferation, neuronal differentiation phenotyping, and genome-wide CHD7 occupancy assays in iMOP progenitors and iMOP-derived neurons.
[View Publication](https://pubmed.ncbi.nlm.nih.gov/40236205/) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12345466/) Singulator 100
### Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal Cellular Heterogeneity and Intercellular Communication Networks in the Hypothalamus-Pituitary-Ovarian Axis of Pregnant Mongolian Cattle
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12345466/) [Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_final_v1.pdf) Singulator 200+
### Brochure - Singulator 200+
[Download Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_final_v1.pdf) [Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_FFPE_final_v1.pdf) Singulator 200+
### Brochure - S200+ - FFPE
[Download Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/S200_Brochure_FFPE_final_v1.pdf) [Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/Moxi_GO_II_Brochure.pdf) Moxi GO II
### Brochure - Moxi GO II
[Download Brochure](https://precisioncellsystems.com/wp-content/uploads/2025/12/Moxi_GO_II_Brochure.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/11/Applicaiton_Note_Singulator_FFPE_v1_11-30-25.pdf) Singulator 200+
### FFPE Tissue Dissociation
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/11/Applicaiton_Note_Singulator_FFPE_v1_11-30-25.pdf) [Blog Part 3](/resources/brain-map-part-3-fresh-vs-frozen-which-side-are-you-on/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 3: Fresh vs. Frozen: Which Side Are You On?

Fresh vs. Frozen: Which Side Are You On? Description: The debate between fresh tissue (whole cells) and frozen tissue (nuclei) divides labs. We explore why fresh dissociation often creates a "map of a disaster" through stress artifacts, and why frozen nuclei offer the unbiased, stable truth required for atlas-scale science.
[Read Blog](/resources/brain-map-part-3-fresh-vs-frozen-which-side-are-you-on/) [Blog Part 4](/resources/brain-map-part-4-the-list-is-good-but-is-the-map-better/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 4: The List is Good, But Is the Map Better?

The List is Good, But Is the Map Better? Description: Single-nucleus sequencing gives you the "List" of cell types, but Spatial Transcriptomics gives you the "Map." Discover how combining these technologies creates a high-resolution "Precision Point," and how one automated platform can serve as the engine for both workflows.
[Read Blog](/resources/brain-map-part-4-the-list-is-good-but-is-the-map-better/) [Blog Part 5](/resources/brain-map-part-5-the-journey-ends-here-are-you-ready-to-build-the-map/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 5: The Journey Ends Here - Are You Ready to Build the Map?

From the hidden world of glia to the final 3D atlas, the journey of modern neuroscience relies on one foundational step: sample preparation. We conclude our series by challenging researchers to prioritize clean, reproducible input to build the definitive map of the human brain.
[Read Blog](/resources/brain-map-part-5-the-journey-ends-here-are-you-ready-to-build-the-map/) [Blog Part 1](/resources/brain-map-part-1-why-did-science-miss-half-the-brain/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 1: Why Did Science Miss Half the Brain?

For a century, neuroscience focused exclusively on the neuron, dismissing glia as mere "packing peanuts." Discover how single-nucleus sequencing revealed the active, critical role of the brain's immune and support systems—and why this shift changes everything for Alzheimer's research.
[Read Blog](/resources/brain-map-part-1-why-did-science-miss-half-the-brain/) [Blog Part 2](/resources/brain-map-part-2-what-is-ruining-your-frozen-experiments/) Singulator 100 Singulator 200 Singulator 200+
### Brain Map - Part 2: What is Ruining Your Frozen Experiments?

What is Ruining Your Frozen Experiments? Description: Every great story needs a villain. In frozen brain tissue processing, that villain is myelin debris. Learn how lipid contamination clogs microfluidics and ruins data, and see how the Singulator’s automated Protocol DP0006 neutralizes this threat to unlock biobank archives.
[Read Blog](/resources/brain-map-part-2-what-is-ruining-your-frozen-experiments/) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/11/2025-11-05_Precision-Cell-Systems_-Automating-Tissue-Dissociation-for-Single-Cell-Analysis.mp4) Singulator 100 Singulator 200
### Webinar 11-5-25: Automating Tissue Dissociation for Single Cell Analysis
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/11/2025-11-05_Precision-Cell-Systems_-Automating-Tissue-Dissociation-for-Single-Cell-Analysis.mp4) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12061129/) Moxi GO II
### Small-scale protocols to characterize mitochondrial Complex V activity and assembly in peripheral blood mononuclear cells
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12061129/) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/Research-Spotlight-Optimizing-Nuclei-Isolation-for-Reliable-snRNA-seq-A-Comparative-Study-Validates-the-SingulatorTM-Platform.pdf) Singulator 100 Singulator 200
### Optimizing Nuclei Isolation for Reliable snRNA-seq - A Comparative Study Validates the Singulator Platform
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/Research-Spotlight-Optimizing-Nuclei-Isolation-for-Reliable-snRNA-seq-A-Comparative-Study-Validates-the-SingulatorTM-Platform.pdf) [Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Single-or-Dual-Color-Viability-Staining-Tech-Tip.pdf) Moxi GO II Moxi V
### Moxi Single or Dual Color Viability Staining Tech Note
[Read Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Single-or-Dual-Color-Viability-Staining-Tech-Tip.pdf) [Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Fluorescence-Based-Reporter-Checks-Tech-Tip.pdf) Moxi GO II
### Moxi Fluorescence-Based Reporter Checks Tech Note
[Read Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Fluorescence-Based-Reporter-Checks-Tech-Tip.pdf) [Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Immunoprofiling-Tech-Tip.pdf) Moxi GO II
### Moxi Immunoprofiling Tech Note
[Read Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Immunoprofiling-Tech-Tip.pdf) [Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Nuclei-Counting-Tech-Tip.pdf) Moxi GO II Moxi V
### Moxi Nuclei Counting Tech Note
[Read Tech Note](https://precisioncellsystems.com/wp-content/uploads/2025/09/ORFLO-Nuclei-Counting-Tech-Tip.pdf) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC4850312/) Moxi Z
### Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC4850312/) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC5350271/) Moxi Z
### Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC5350271/) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC7958435/) Moxi Z
### Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC7958435/) [Publication](https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30877-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580720308777%3Fshowall%3Dtrue) Moxi GO II
### A Single-Cell Transcriptomic Atlas of Human Skin Aging
[View Publication](https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30877-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580720308777%3Fshowall%3Dtrue) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC6532103/) Moxi GO II
### Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC6532103/) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC8240505/) Moxi GO II
### A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC8240505/) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-III.mp4) Singulator 100 Singulator 200
### Singulator Sessions III: Unlock the Potential of Your Neuroscience Samples with the Singulator Platform Singulator Session III
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-III.mp4) [Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-I.mp4) Singulator 100 Singulator 200
### Singulator Session I: Automating Tissue Dissociation for Single-Cell Analysis
[Watch Webinar](https://precisioncellsystems.com/wp-content/uploads/2025/08/Singulator-Session-I.mp4) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Average-Cell-Size-By-Cell-Type.pdf) Moxi GO II Moxi V Moxi Z
### Moxi - Average Cell Size By Cell Type
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Average-Cell-Size-By-Cell-Type.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Immunophenotyping-Applications.pdf) Moxi GO II
### Moxi - Immunophenotyping Applications
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Immunophenotyping-Applications.pdf) [App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Monitoring-Cell-Culture-Health-and-MPI-With-the-Moxi-Z.pdf) Moxi Z
### Moxi - Monitoring Cell Culture Health and MPI With the Moxi Z
[Download App Note](https://precisioncellsystems.com/wp-content/uploads/2025/08/Moxi-Monitoring-Cell-Culture-Health-and-MPI-With-the-Moxi-Z.pdf) [Publication](https://precisioncellsystems.com/wp-content/uploads/2025/10/s41586-022-05450-1.pdf) Singulator 100 Singulator 200
### Kinase signaling in excitatory neurons regulates sleep quantity and depth
[View Publication](https://precisioncellsystems.com/wp-content/uploads/2025/10/s41586-022-05450-1.pdf) [Publication](https://link.springer.com/article/10.1007/s00401-023-02604-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.31.1743558253016&__hsfp=1300058700&submissionGuid=c7f3c611-02ec-4ec0-a180-2e24c56a4025) Singulator 100 Singulator 200
### Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy
[View Publication](https://link.springer.com/article/10.1007/s00401-023-02604-x?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.31.1743558253016&__hsfp=1300058700&submissionGuid=c7f3c611-02ec-4ec0-a180-2e24c56a4025) [Publication](https://www.biorxiv.org/content/10.1101/2023.11.17.567534v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.26.1743558253016&__hsfp=1300058700&submissionGuid=838128d8-35f7-458b-a0a0-6e5e93506818) Singulator 100 Singulator 200
### Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
[View Publication](https://www.biorxiv.org/content/10.1101/2023.11.17.567534v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.26.1743558253016&__hsfp=1300058700&submissionGuid=838128d8-35f7-458b-a0a0-6e5e93506818) [Presentation](https://sail.mskcc.org/research/experimental-research/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.1.1743114390284&__hsfp=1300058700&submissionGuid=da42544b-9315-47f8-87f4-f27614a8159e) Singulator 100 Singulator 200
### Comparison of polydT and probe-based RNA capture for single-cell RNAseq
[View Presentation](https://sail.mskcc.org/research/experimental-research/?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743110139007.1743114390284.6&__hssc=225964101.1.1743114390284&__hsfp=1300058700&submissionGuid=da42544b-9315-47f8-87f4-f27614a8159e) [Protocol](https://www.protocols.io/view/1-perff-seq-cell-and-nuclei-preparation-c8n3zvgn.html?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.3.1743120525713&__hsfp=1300058700&submissionGuid=cb652c05-65bb-4462-94bc-f6d6270950ee) Singulator 200+
### PERFF-seq: Cell and Nuclei Preparation
[Read Protocol](https://www.protocols.io/view/1-perff-seq-cell-and-nuclei-preparation-c8n3zvgn.html?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.3.1743120525713&__hsfp=1300058700&submissionGuid=cb652c05-65bb-4462-94bc-f6d6270950ee) [Protocol](https://www.jove.com/t/65611/a-simple-quick-partially-automated-protocol-for-isolation-single?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.6.1743120525713&__hsfp=1300058700&submissionGuid=d251dea3-f5b9-441b-b0eb-4eadf390de7e) Singulator 100 Singulator 200
### A Simple, Quick, and Partially Automated Protocol for the Isolation of Single Nuclei from Frozen Mammalian Tissues for Single Nucleus Sequencing
[Read Protocol](https://www.jove.com/t/65611/a-simple-quick-partially-automated-protocol-for-isolation-single?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.6.1743120525713&__hsfp=1300058700&submissionGuid=d251dea3-f5b9-441b-b0eb-4eadf390de7e) [Protocol](https://www.protocols.io/view/nuclei-extraction-for-single-cell-rnaseq-from-froz-q26g74xzqgwz/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.13.1743120525713&__hsfp=1300058700&submissionGuid=cc1fb887-2fc0-423d-9124-6e7264b1d55f) Singulator 100 Singulator 200
### Nuclei extraction for single-cell RNAseq from frozen tissue using Singulator™ 100
[Read Protocol](https://www.protocols.io/view/nuclei-extraction-for-single-cell-rnaseq-from-froz-q26g74xzqgwz/v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743114390284.1743120525713.7&__hssc=225964101.13.1743120525713&__hsfp=1300058700&submissionGuid=cc1fb887-2fc0-423d-9124-6e7264b1d55f) [Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12276987/) Singulator 200+
### Transcript-specific enrichment enables profiling rare cell states via scRNA-seq
[View Publication](https://pmc.ncbi.nlm.nih.gov/articles/PMC12276987/) [Publication](https://aacrjournals.org/cancerres/article/85/2/231/750993/FOXR2-Targets-LHX6-DLX-Neural-Lineages-to-Drive) Singulator 100 Singulator 200
### FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma
[View Publication](https://aacrjournals.org/cancerres/article/85/2/231/750993/FOXR2-Targets-LHX6-DLX-Neural-Lineages-to-Drive) [Publication](https://www.biorxiv.org/content/10.1101/2024.09.19.613680v2?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.10.1743558253016&__hsfp=1300058700&submissionGuid=fefae69e-e5ef-46cc-94e1-7f2a6872a7d6) Singulator 100 Singulator 200
### High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells
[View Publication](https://www.biorxiv.org/content/10.1101/2024.09.19.613680v2?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.10.1743558253016&__hsfp=1300058700&submissionGuid=fefae69e-e5ef-46cc-94e1-7f2a6872a7d6) [Publication](https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00628-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.18.1743558253016&__hsfp=1300058700&submissionGuid=ab722450-c4b5-4fb8-9824-6d715a4fe27d) Singulator 100 Singulator 200
### Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
[View Publication](https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00628-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.18.1743558253016&__hsfp=1300058700&submissionGuid=ab722450-c4b5-4fb8-9824-6d715a4fe27d) [Publication](https://www.biorxiv.org/content/10.1101/2024.07.03.601895v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.19.1743558253016&__hsfp=1300058700&submissionGuid=9c9dd609-839a-4835-bdfe-9a55a15ddfab) Singulator 100 Singulator 200
### An orbitocortical-thalamic circuit suppresses binge alcohol-drinking
[View Publication](https://www.biorxiv.org/content/10.1101/2024.07.03.601895v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.19.1743558253016&__hsfp=1300058700&submissionGuid=9c9dd609-839a-4835-bdfe-9a55a15ddfab) [Publication](https://www.biorxiv.org/content/10.1101/2024.06.27.601103v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.20.1743558253016&__hsfp=1300058700&submissionGuid=dfdb8bf0-7f4d-4b64-909b-c4678cd4b48c) Singulator 100 Singulator 200
### Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia
[View Publication](https://www.biorxiv.org/content/10.1101/2024.06.27.601103v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.20.1743558253016&__hsfp=1300058700&submissionGuid=dfdb8bf0-7f4d-4b64-909b-c4678cd4b48c) [Publication](https://www.biorxiv.org/content/10.1101/2024.07.01.601334v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.22.1743558253016&__hsfp=1300058700&submissionGuid=3a510c1b-ea13-4041-84cf-21b9345137b2) Singulator 100 Singulator 200
### Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic NF1 mutant glioblastoma
[View Publication](https://www.biorxiv.org/content/10.1101/2024.07.01.601334v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.22.1743558253016&__hsfp=1300058700&submissionGuid=3a510c1b-ea13-4041-84cf-21b9345137b2) [Publication](https://www.biorxiv.org/content/10.1101/2024.04.26.587806v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.23.1743558253016&__hsfp=1300058700&ct=&submissionGuid=2ff5c384-7040-4df8-91c6-30eaae489b4f) Singulator 100 Singulator 200
### High-resolution detection of copy number alterations in single cells with HiScanner
[View Publication](https://www.biorxiv.org/content/10.1101/2024.04.26.587806v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.23.1743558253016&__hsfp=1300058700&ct=&submissionGuid=2ff5c384-7040-4df8-91c6-30eaae489b4f) [Publication](https://www.nature.com/articles/s41587-024-02193-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.24.1743558253016&__hsfp=1300058700&submissionGuid=d4eb5dac-02d7-45d8-953c-6c79fc38c05f) Singulator 200+
### The covariance environment defines cellular niches for spatial inference
[View Publication](https://www.nature.com/articles/s41587-024-02193-4?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.24.1743558253016&__hsfp=1300058700&submissionGuid=d4eb5dac-02d7-45d8-953c-6c79fc38c05f) [Publication](https://www.science.org/doi/10.1126/sciadv.adn4649?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.25.1743558253016&__hsfp=1300058700&submissionGuid=7cb6bf68-0d64-411b-96de-7235ff6475e4) Singulator 100 Singulator 200
### Childhood cancer mutagenesis caused by transposase-derived PGBD5
[View Publication](https://www.science.org/doi/10.1126/sciadv.adn4649?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.25.1743558253016&__hsfp=1300058700&submissionGuid=7cb6bf68-0d64-411b-96de-7235ff6475e4) [Publication](https://www.biorxiv.org/content/10.1101/2023.08.19.553427v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.29.1743558253016&__hsfp=1300058700&ct=&submissionGuid=a4f220b8-1b13-4953-9b56-b675ed8faf9a) Singulator 100 Singulator 200
### Neuronal SNCA transcription during Lewy body formation
[View Publication](https://www.biorxiv.org/content/10.1101/2023.08.19.553427v1?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.29.1743558253016&__hsfp=1300058700&ct=&submissionGuid=a4f220b8-1b13-4953-9b56-b675ed8faf9a) [Publication](https://www.sciencedirect.com/science/article/pii/S0092867423001666?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.32.1743558253016&__hsfp=1300058700&submissionGuid=14a4fa98-f109-4563-98aa-4aa9ea18fe6b) Singulator 100 Singulator 200
### Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
[View Publication](https://www.sciencedirect.com/science/article/pii/S0092867423001666?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.32.1743558253016&__hsfp=1300058700&submissionGuid=14a4fa98-f109-4563-98aa-4aa9ea18fe6b) [Publication](https://www.nature.com/articles/s41588-022-01205-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.36.1743558253016&__hsfp=1300058700&submissionGuid=16d6bd6f-42f1-45ab-b755-85d2fc136d9a) Singulator 100 Singulator 200
### K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
[View Publication](https://www.nature.com/articles/s41588-022-01205-w?__hstc=225964101.fe4380f775ce29a6a07134828a8c07b8.1742318073258.1743189924157.1743558253016.10&__hssc=225964101.36.1743558253016&__hsfp=1300058700&submissionGuid=16d6bd6f-42f1-45ab-b755-85d2fc136d9a)
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